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Article

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

Genes & development - 15 Dec 2004

McLean Gordon W, Komiyama Noboru H, Serrels Bryan, Asano Hidefumi, Reynolds Louise, Conti Francesco, Hodivala-Dilke Kairbaan, Metzger Daniel, Chambon Pierre, Grant Seth G N, Frame Margaret C

Abstract excerpt

We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre fused to a modified estrogen receptor (CreER(T2)). 4-Hydroxy-tamoxifen treatment induced fak deletion in the epidermis, and suppressed chemically induced skin tumor formation. Loss of fak induced once benign tumors had formed inhibited malignant progression. Although fak deletion was associated with reduced migration of...

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Identifiers

PMID: 15601818
DOI: 10.1101/gad.316304
PMCID: PMC535910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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