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Article

Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.

The Journal of biological chemistry - 11 Dec 2009

Corsi Jean-Marc, Houbron Christophe, Billuart Pierre, Brunet Isabelle, Bouvrée Karine, Eichmann Anne, Girault Jean-Antoine, Enslen Hervé

Abstract excerpt

Focal adhesion kinase (FAK) regulates numerous cellular functions and is critical for processes ranging from embryo development to cancer progression. Although autophosphorylation on Tyr-397 appears required for FAK functions in vitro, its role in vivo has not been established. We addressed this question using a mutant mouse (fakDelta) deleted of exon 15, which encodes Tyr-397. The resulting mutant protein...

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Source

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Identifiers

PMID: 19776009
DOI: 10.1074/jbc.M109.067280
PMCID: PMC2787339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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