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Article

Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts.

The Journal of biological chemistry - 1 Aug 2003

Funakoshi-Tago Megumi, Sonoda Yoshiko, Tanaka Saeko, Hashimoto Kenichiro, Tago Kenji, Tominaga Shin-Ichi, Kasahara Tadashi

Abstract excerpt

Focal adhesion kinase (FAK) is widely involved in important cellular functions such as proliferation, migration, and survival, although its roles in immune and inflammatory responses have yet to be explored. We demonstrate a critical role for FAK in the tumor necrosis factor (TNF)-induced activation of nuclear factor (NF)-kappaB, using FAK-deficient (FAK-/-) embryonic fibroblasts. Interestingly, TNF-induced...

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12748169
DOI: 10.1074/jbc.M213115200

Genes

TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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