Article
Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.
The Biochemical journal - 1 Aug 2002
Gabarra-Niecko Veronica, Keely Patricia J, Schaller Michael D
Abstract excerpt
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in normal cellular processes such as adhesion, spreading, migration, proliferation and survival. In addition, FAK is overexpressed in a variety of cancer cells and tumours and may play a role in the development of human cancer. As a prelude to modelling the role of aberrant FAK signalling in the initiation of cancer, the...
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