Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

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Article

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

Oncogene - 16 Nov 1995

Furuta Y, Ilić D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S

Abstract excerpt

FAK is a unique non-receptor protein tyrosine kinase that was found in cellular focal adhesions. An increasing number of in vitro observations has suggested that FAK mediates signaling through integrins brought about by interactions with extracellular matrix (ECM). It is highly tyrosine-phosphory...

Topics

Animals
Base Sequence
Cell Adhesion Molecules
Extracellular Matrix
Female
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Gastrula
Heterozygote
Homozygote
Kanamycin Kinase
Male
Mesoderm
Mice
Mice, Inbred Strains
Molecular Sequence Data
Mutation
Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed

Identifiers

PMID: 7478517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7478517-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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