Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Marfan-like skeletal phenotype in the tight skin (Tsk) mouse.

Calcified tissue international - 1 Oct 2007

Barisic-Dujmovic Tatjana, Boban Ivana, Adams Douglas J, Clark Stephen H

Abstract excerpt

Tight skin (Tsk) is an autosomal dominant mutation located on mouse chromosome 2 and is associated with an intragenic duplication of the fibrillin 1 (Fbn1) gene. Mutant mice (Tsk/+) display a tightness of skin in the interscapular region, lung emphysema, myocardial hypertrophy, skeletal overgrowth, and kyphosis. It is hypothesized in this study that in Tsk mice the mutation in Fbn1 alters bone cell metabolism. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Femur
Share to Histocytochemistry
Share to Marfan Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Osteocalcin

Share to Sialoglycoproteins

Share to Skin Abnormalities

Share to Stromal Cells

Source

Identifiers

PMID: 17705049
DOI: 10.1007/s00223-007-9059-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Marfan-like skeletal phenotype in the tight skin (Tsk) mouse.PMID 17705049Read ↗

New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse.Semantic proximity Read ↗

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.Semantic proximity Read ↗

The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils.Semantic proximity Read ↗

Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.Semantic proximity Read ↗

Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis.Semantic proximity Read ↗

Regulation of collagen gene expression in the Tsk2 mouse.Semantic proximity Read ↗

Analysis of the tight skin (Tsk1/+) mouse as a model for testing antifibrotic agents.Semantic proximity Read ↗

The tight skin 2 mouse. An animal model of scleroderma displaying cutaneous fibrosis and mononuclear cell infiltration.Semantic proximity Read ↗

Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15.Semantic proximity Read ↗

Fibrillin-1 protein in tight skin mice and scleroderma.Semantic proximity Read ↗

Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice.Semantic proximity Read ↗

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.