Article
Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 1997
Hua V Y, Wang W K, Duesberg P H
Abstract excerpt
The gene-mutation-cancer hypothesis holds that mutated cellular protooncogenes, such as point-mutated proto-ras, "play a dominant part in cancer," because they are sufficient to transform transfected mouse cell lines in vitro [Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. & Watson, J. D. (1994) Molecular Biology of the Cell (Garland, New York)]. However, in cells transformed in vitro mutated human ras...
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