Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis.

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Article

Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis.

Oncogene - 5 Sept 1996

Mangues R, Symmans W F, Lu S, Schwartz S, Pellicer A

Abstract excerpt

We compared the tumorigenic effects of the N-ras oncogene and the N-ras proto-oncogene in lymphoid and mammary tissues in an in vivo model. For this purpose, we generated transgenic mice with high levels of N-ras oncogene or N-ras proto-oncogene expression, driven by the complete mouse mammary tu...

Topics

Animals
Breast
Carcinoma
Flow Cytometry
Gene Expression Regulation, Neoplastic
Genes, ras
Incidence
Lymphoma, B-Cell
Lymphoma, T-Cell
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mice, Transgenic
Mutation
Repetitive Sequences, Nucleic Acid
Signal Transduction
Spleen
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 8806695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8806695-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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