Article
Predisposition to neoplastic transformation caused by gene replacement of H-ras1.
Science (New York, N.Y.) - 4 Jun 1993
Finney R E, Bishop J M
Abstract excerpt
Homologous recombination was used to introduce a nominally transforming mutation into an endogenous H-ras1 gene in Rat1 fibroblasts. Although both the mutant and the remaining normal allele were expressed equally, the heterozygous cells were not neoplastically transformed. Instead, spontaneously...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Genes, ras
- Mice
- Mice, Nude
- Molecular Sequence Data
- Neoplasm Transplantation
- Point Mutation
- Rats
- Recombination, Genetic