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Article

Suppression of gene amplification in human cell hybrids.

Science (New York, N.Y.) - 13 Mar 1992

Tlsty T D, White A, Sanchez J

Abstract excerpt

Gene amplification, one example of genetic instability, is of prognostic and clinical importance in neoplasia. In tumorigenic cells, gene amplification occurs at a very high frequency, whereas in normal diploid fibroblasts the event is undetectable by the clonogenic assay. To investigate genetic control of gene amplification, amplification frequency was measured in hybrids of tumorigenic cells and normal diploid...

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Identifiers

PMID: 1542791
DOI: 10.1126/science.1542791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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