Suppression of gene amplification in human cell hybrids.

doi:10.1126/science.1542791

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Article

Suppression of gene amplification in human cell hybrids.

Science (New York, N.Y.) - 13 Mar 1992

Tlsty T D, White A, Sanchez J

Abstract excerpt

Gene amplification, one example of genetic instability, is of prognostic and clinical importance in neoplasia. In tumorigenic cells, gene amplification occurs at a very high frequency, whereas in normal diploid fibroblasts the event is undetectable by the clonogenic assay. To investigate genetic...

Topics

Aspartate Carbamoyltransferase
Aspartic Acid
Cell Line
Cell Transformation, Neoplastic
Drug Resistance
Gene Amplification
Gene Expression Regulation, Enzymologic
Genes, Dominant
Genes, Recessive
Humans
Hybrid Cells
Mutation
Phenotype
Phosphonoacetic Acid
Suppression, Genetic
Tumor Cells, Cultured

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