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Article

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene.

Cancer research - 1 Aug 2002

Diaz Roberto, Ahn Daniel, Lopez-Barcons Lluis, Malumbres Marcos, Perez de Castro Ignacio, Lue Jeffrey, Ferrer-Miralles Neus, Mangues Ramon, Tsong Jerry, Garcia Roberto, Perez-Soler Roman, Pellicer Angel

Abstract excerpt

ras proto-oncogenes have traditionally been associated with the regulation and promotion of cell growth. We have induced thymic lymphomas in N-ras(-/-) mice and in transgenic mice that overexpress wild-type N-ras and found that the lack of wild-type N-ras alleles favors the development of thymic lymphomas,whereas overexpression of wild-type N-ras protects against thymic lymphomagenesis in the presence or absence...

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PMID: 12154063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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