Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice.

Article

Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice.

Oncogene - 1 Oct 1992

Mangues R, Seidman I, Gordon J W, Pellicer A

Abstract excerpt

We have produced transgenic mice that carry a foreign gene construct consisting of the N-ras proto-oncogene driven by the mouse mammary tumor virus (MMTV) long terminal repeat. Overexpression of the normal N-ras gene is associated with development of hyperplasias and tumors in a variety of tissue...

Topics

Animals
Base Sequence
Gene Expression
Genes, ras
Mammary Tumor Virus, Mouse
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Neoplasms, Experimental

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