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Article

Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1997

Raptis L, Brownell H L, Corbley M J, Wood K W, Wang D, Haliotis T

Abstract excerpt

To investigate the role of the cellular ras gene product in neoplastic transformation by the SV40 large tumor antigen (SVLT), murine C3H10T1/2 cells were rendered deficient in Ras activity by transfection with inducible or constitutive antisense ras gene constructs or through the introduction of the dominant-negative mutant, ras(asn17). Consistent with previous results, SVLT-induced morphological transformation...

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PMID: 9269898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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