Gene expression, cellular diversification and tumor progression to the metastatic phenotype.

doi:10.1002/bies.950130706

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Article

Gene expression, cellular diversification and tumor progression to the metastatic phenotype.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jul 1991

Nicolson G L

Abstract excerpt

Alterations in the expression of certain genes or in their products can render benign tumor cells metastatic. Experimentally this has been quickly performed by transferring dominantly acting oncogenes such as c-H-rasEJ into susceptible cells, but in vivo such a rapid qualitative change in a dominantly acting oncogene occurs only rarely, and progression to highly metastatic phenotypes is thought to occur through a...

Topics

Animals
Cell Differentiation
Clone Cells
Fibroblasts
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Growth Substances
Humans
Mice
Neoplasm Metastasis
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Neoplasms, Experimental

Oncogenes

Phenotype

Rats

Selection, Genetic

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1759975
DOI: 10.1002/bies.950130706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1759975-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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