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Article

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

Science (New York, N.Y.) - 29 Aug 1997

Sinclair D A, Mills K, Guarente L

Abstract excerpt

The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the...

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Identifiers

PMID: 9271578
DOI: 10.1126/science.277.5330.1313

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.PMID 9271578Read ↗

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

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Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.Semantic proximity Read ↗

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