Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

doi:10.1126/science.277.5330.1313

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

Science (New York, N.Y.) - 29 Aug 1997

Sinclair D A, Mills K, Guarente L

Abstract excerpt

The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and t...

Topics

Cell Division
Cell Nucleolus
Cellular Senescence
DNA Helicases
Exodeoxyribonucleases
Fluorescent Antibody Technique, Indirect
Fungal Proteins
Genes, Fungal
Humans
Mutation
Phenotype
RecQ Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Silent Information Regulator Proteins, Saccharomyces cerevisiae

Trans-Activators

Werner Syndrome

Werner Syndrome Helicase

Source

Open in PubMed

Identifiers

PMID: 9271578
DOI: 10.1126/science.277.5330.1313

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9271578-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.PMID 9271578Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

Recent Advances in Understanding Werner SyndromeSemantic proximity Read ↗

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.Semantic proximity Read ↗

Werner syndrome: genetic and molecular basis of a premature aging disorder.Semantic proximity Read ↗

Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.Semantic proximity Read ↗

Requirement of yeast SGS1 and SRS2 genes for replication and transcription.Semantic proximity Read ↗

Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.Semantic proximity Read ↗

Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner SyndromeSemantic proximity Read ↗

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human agingSemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.