Article
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.
DNA repair - 6 Aug 2002
Branzei Dana, Seki Masayuki, Onoda Fumitoshi, Yagi Hideki, Kawabe Yoh-ichi, Enomoto Takemi
Abstract excerpt
RecQ DNA helicases from many organisms have been indicated to function in the maintenance of genomic stability. In human cells, mutation in the WRN helicase, a RecQ-like DNA helicase, results in the Werner syndrome (WS), a genetic disorder characterized by genomic instability and premature ageing. Similarly, mutation in SGS1, the RECQ homologue in budding yeast, results in genomic instability and accelerated...
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