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Article

Requirement of yeast SGS1 and SRS2 genes for replication and transcription.

Science (New York, N.Y.) - 17 Dec 1999

Lee S K, Johnson R E, Yu S L, Prakash L, Prakash S

Abstract excerpt

The SGS1 gene of the yeast Saccharomyces cerevisiae encodes a DNA helicase with homology to the human Bloom's syndrome gene BLM and the Werner's syndrome gene WRN. The SRS2 gene of yeast also encodes a DNA helicase. Simultaneous deletion of SGS1 and SRS2 is lethal in yeast. Here, using a conditional mutation of SGS1, it is shown that DNA replication and RNA polymerase I transcription are drastically inhibited in...

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Source

Identifiers

PMID: 10600744
DOI: 10.1126/science.286.5448.2339

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of yeast SGS1 and SRS2 genes for replication and transcription.PMID 10600744Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.Semantic proximity Read ↗

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

Different domains of Sgs1 are required for mitotic and meiotic functions.Semantic proximity Read ↗

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.Semantic proximity Read ↗

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.Semantic proximity Read ↗

SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.Semantic proximity Read ↗

SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae.Semantic proximity Read ↗

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