Article
Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning.
Biochemical pharmacology - 15 Jul 1997
Saxena A, Maxwell D M, Quinn D M, Radić Z, Taylor P, Doctor B P
Abstract excerpt
It has been demonstrated that cholinesterases (ChEs) are an effective mode of pretreatment to prevent organophosphate (OP) toxicity in mice and rhesus monkeys. The efficacy of ChE as a bioscavenger of OP can be enhanced by combining enzyme pretreatment with oxime reactivation, since the scavenging capacity extends beyond a stoichiometric ratio of ChE to OP. Aging has proven to be a major barrier to achieving...
Topics
- Acetylcholinesterase
- Animals
- Cholinesterase Inhibitors
- Enzyme Reactivators
- Hydrogen-Ion Concentration
- Inactivation, Metabolic
- Mice
- Mutation
- Organophosphorus Compounds
- Oximes
- Pyridinium Compounds
- Torpedo