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Article

Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates.

Toxicology - 20 Apr 2007

Kovarik Zrinka, Radić Zoran, Berman Harvey A, Taylor Palmer

Abstract excerpt

Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate. Through enlargement of the active site gorge of mouse AChE by...

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Identifiers

PMID: 17046138
DOI: 10.1016/j.tox.2006.08.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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