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Article

Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.

Chemistry & biology - 20 Apr 2012

Goldsmith Moshe, Ashani Yacov, Simo Yair, Ben-David Moshe, Leader Haim, Silman Israel, Sussman Joel L, Tawfik Dan S

Abstract excerpt

A preferred strategy for preventing nerve agents intoxication is catalytic scavenging by enzymes that hydrolyze them before they reach their targets. Using directed evolution, we simultaneously enhanced the activity of a previously described serum paraoxonase 1 (PON1) variant for hydrolysis of the toxic S(P) isomers of the most threatening G-type nerve agents. The evolved variants show ≤340-fold increased rates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22520752
DOI: 10.1016/j.chembiol.2012.01.017

Genes

PON1

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