Article
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
Toxicology letters - 25 Sept 2011
Trovaslet-Leroy Marie, Musilova Lucie, Renault Frédérique, Brazzolotto Xavier, Misik Jan, Novotny Ladislav, Froment Marie-Thérèse, Gillon Emilie, Loiodice Mélanie, Verdier Laurent, Masson Patrick, Rochu Daniel, Jun Daniel, Nachon Florian
Abstract excerpt
Bioscavengers are molecules able to neutralize neurotoxic organophosphorus compounds (OP) before they can reach their biological target. Human butyrylcholinesterase (hBChE) is a natural bioscavenger each molecule of enzyme neutralizing one molecule of OP. The amount of natural enzyme is insufficient to achieve good protection. Thus, different strategies have been envisioned. The most straightforward consists in...
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