Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

doi:10.1016/j.tox.2006.11.061

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Article

Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

Toxicology - 20 Apr 2007

Taylor Palmer, Kovarik Zrinka, Reiner Elsa, Radić Zoran

Abstract excerpt

Applications of recombinant DNA technology, chemical synthesis on biological templates and fluorescence detection of organophosphorylation provide unexplored avenues for development of antidotes and approaches for remote detection of organophosphate nerve agents and pesticides. We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation. Since the...

Topics

Acetylcholinesterase
Antidotes
Binding, Competitive
Catalysis
Cholinesterase Inhibitors
Cholinesterase Reactivators
Drug Design
Humans
Hydrolysis
Ligands
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutation

Organophosphate Poisoning

Organophosphorus Compounds

Oximes

Poisoning

Spectrometry, Fluorescence

Source

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Identifiers

PMID: 17196318
DOI: 10.1016/j.tox.2006.11.061
PMCID: PMC3279330

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