Article
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Archives of toxicology - 1 Nov 2016
Goldsmith Moshe, Eckstein Simone, Ashani Yacov, Greisen Per, Leader Haim, Sussman Joel L, Aggarwal Nidhi, Ovchinnikov Sergey, Tawfik Dan S, Baker David, Thiermann Horst, Worek Franz
Abstract excerpt
The nearly 200,000 fatalities following exposure to organophosphorus (OP) pesticides each year and the omnipresent danger of a terroristic attack with OP nerve agents emphasize the demand for the development of effective OP antidotes. Standard treatments for intoxicated patients with a combination of atropine and an oxime are limited in their efficacy. Thus, research focuses on developing catalytic bioscavengers...
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