Article
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.
PloS one - 18 Mar 2011
Hemmert Andrew C, Otto Tamara C, Chica Roberto A, Wierdl Monika, Edwards Jonathan S, Lewis Steven M, Lewis Steven L, Edwards Carol C, Tsurkan Lyudmila, Cadieux C Linn, Kasten Shane A, Cashman John R, Mayo Stephen L, Potter Philip M, Cerasoli Douglas M, Redinbo Matthew R
Abstract excerpt
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activity into the human drug metabolism enzyme carboxylesterase 1. Using crystal structures of the target enzyme in complex...
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