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Article

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

Pharmacogenetics - 1 Jun 1996

Lachman H M, Papolos D F, Saito T, Yu Y M, Szumlanski C L, Weinshilboum R M

Abstract excerpt

Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism in humans is associated with a three-to-four-fold variation in COMT enzyme activity and is also associated with individual variation in COMT thermal instability. We now...

Topics

Catechol O-Methyltransferase
Genotype
Heterozygote
Homozygote
Humans
Molecular Sequence Data
Mood Disorders
Pharmacogenetics
Phenotype
Polymorphism, Genetic
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8807664
DOI: 10.1097/00008571-199606000-00007

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8807664-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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