Article
High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease.
Neuroscience letters - 17 Jan 1997
Kunugi H, Nanko S, Ueki A, Otsuka E, Hattori M, Hoda F, Vallada H P, Arranz M J, Collier D A
Abstract excerpt
Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Recently an amino acid change (Val-108-Met) of the COMT protein was found to determine high and low activity alleles of the COMT gene. We genotyped 109 Japanese patients with Parkinson's disease (PD) and 153 controls by using polymerase chain reaction (PCR) amplification and...
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