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Article

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.

The American journal of psychiatry - 1 Feb 1996

Daniels J K, Williams N M, Williams J, Jones L A, Cardno A G, Murphy K C, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen M J

Abstract excerpt

OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Some previous studies using biochemical methods have found higher levels of COMT activity in schizophrenic patients. Recently, the genetic polymorphism that underlies variation in COMT activity, which results in the creation of a NlaIII restriction site in the low-activity allele, has been elucidated....

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Source

Identifiers

PMID: 8561211
DOI: 10.1176/ajp.153.2.268

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.PMID 8561211Read ↗

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