Article
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.
The American journal of psychiatry - 1 Feb 1996
Daniels J K, Williams N M, Williams J, Jones L A, Cardno A G, Murphy K C, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen M J
Abstract excerpt
OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Some previous studies using biochemical methods have found higher levels of COMT activity in schizophrenic patients. Recently, the genetic polymorphism that underlies variation in COMT...
Topics
- Alleles
- Base Sequence
- Catechol O-Methyltransferase
- Female
- Genotype
- Humans
- Male
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- Schizophrenia