Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

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Article

Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

Cancer research - 15 Nov 1992

Toguchida J, Yamaguchi T, Ritchie B, Beauchamp R L, Dayton S H, Herrera G E, Yamamuro T, Kotoura Y, Sasaki M S, Little J B

Abstract excerpt

We present here an analysis of the spectrum of mutations of the p53 gene seen in 127 bone and soft tissue sarcomas of various histological classifications. Gross rearrangements were analyzed by Southern blotting using a complementary DNA probe from the p53 gene, and subtle alterations in the enti...

Topics

Alleles
Base Sequence
Blotting, Southern
Bone Neoplasms
Exons
Gene Deletion
Gene Rearrangement
Genes, p53
Humans
Molecular Sequence Data
Mutation
Osteosarcoma
Phenotype
Sarcoma
Soft Tissue Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1423262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1423262-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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