Article
Overexpression of the oncoprotein p53 in primary hepatic tumors of childhood does not correlate with gene mutations.
Human pathology - 1 May 1994
Kennedy S M, Macgeogh C, Jaffe R, Spurr N K
Abstract excerpt
High levels of expression of the p53 protein and gene mutations have been described in adult hepatocellular carcinomas. It has been postulated that specific mutations in exon 7 may be caused by aflatoxin exposure. To determine whether p53 mutations occur in childhood liver cancer unassociated with aflatoxin exposure or hepatitis B virus (HBV) infection, we have analyzed three histologically distinct tumor types....
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