Article
Overexpression of the oncoprotein p53 in primary hepatic tumors of childhood does not correlate with gene mutations.
Human pathology - 1 May 1994
Kennedy S M, Macgeogh C, Jaffe R, Spurr N K
Abstract excerpt
High levels of expression of the p53 protein and gene mutations have been described in adult hepatocellular carcinomas. It has been postulated that specific mutations in exon 7 may be caused by aflatoxin exposure. To determine whether p53 mutations occur in childhood liver cancer unassociated wit...
Topics
- Base Sequence
- Blotting, Western
- Carcinoma, Hepatocellular
- Child
- Gene Expression Regulation, Neoplastic
- Hepatoblastoma
- Humans
- Immunoenzyme Techniques
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Neoplasms, Germ Cell and Embryonal
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53