Article
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis.
The Journal of allergy and clinical immunology - 1 Jan 2008
Jakob Thilo, Köllisch Gabriele V, Howaldt Maike, Bewersdorff Mayte, Rathkolb Birgit, Müller Marcel L, Sandholzer Nadja, Nitschke Lars, Schiemann Matthias, Mempel Martin, Ollert Markus, Neubauer Antonie, Soewarto Dian A, Kremmer Elisabeth, Ring Johannes, Behrendt Heidrun, Flaswinkel Heinrich
Abstract excerpt
BACKGROUND: Primary cellular immunodeficiencies are a group of genetic disorders in which 1 or more components of the cellular immune system are lacking or dysfunctional. OBJECTIVE: We sought to identify novel mouse mutants that display primary cellular immunodeficiencies. METHODS: Genome-wide N-ethyl-N-nitrosourea mutagenesis was performed in mice, followed by a phenotype screen of immunologic blood parameters....
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