Article
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008
Croker Ben A, Lawson Brian R, Rutschmann Sophie, Berger Michael, Eidenschenk Celine, Blasius Amanda L, Moresco Eva Marie Y, Sovath Sosathya, Cengia Louise, Shultz Leonard D, Theofilopoulos Argyrios N, Pettersson Sven, Beutler Bruce Alan
Abstract excerpt
A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanced resistance to infection by Listeria monocytogenes. TLR-induced TNF and IL-1 production are normal in macrophages...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.