Article
Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.
Clinical immunology and immunopathology - 1 Nov 1994
Bignon J S, Siminovitch K A
Abstract excerpt
Homozygosity for the motheaten (me) or viable motheaten (mev) mutations causes severe dysregulation of murine hematopoiesis with the consequent development of both immunodeficiency and systemic autoimmunity. Expression of this phenotype has now been linked to loss-of-function mutations in the gen...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- Hematopoietic Stem Cells
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Tyrosine Phosphatases