Article
The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS.
Immunological reviews - 1 Oct 2000
O'Brien S J, Moore J P
Abstract excerpt
The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry stimulated a search for common genetic polymorphism in their genes which might affect the course of AIDS. Four mutational variants, CCR5-delta32, CCR5-P1, CCR2-641 and SDF1-3'A were discovered to play a regulatory role in HIV-1 infection,...
Topics
- Acquired Immunodeficiency Syndrome
- Cytokines
- Genetic Variation
- HIV Infections
- HIV-1
- Humans
- Receptors, HIV
- Virus Replication