Article
Absence of p16 gene (CDKN2) deletions in microdissected primary breast carcinoma specimens.
Annals of surgical oncology - 1 Jan 2000
Calvano J E, Rush E B, Tan L K, Rosen P P, Borgen P I, Van Zee K J
Abstract excerpt
BACKGROUND: The p16 gene (CDKN2), a tumor suppressor gene located on chromosome 9p21, has been demonstrated to be mutated or deleted with high frequency in a variety of tumor cell lines, including breast. While previous studies have not demonstrated CDKN2 mutations in primary breast carcinomas, i...
Topics
- Breast Neoplasms
- Carrier Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Electrophoresis, Agar Gel
- Female
- Gene Deletion
- Genes, Tumor Suppressor
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational