Article
Mutations of the p16 gene product are rare in prostate cancer.
The Prostate - 15 Feb 1997
Gaddipati J P, McLeod D G, Sesterhenn I A, Hussussian C J, Tong Y A, Seth P, Dracopoli N C, Moul J W, Srivastava S
Abstract excerpt
BACKGROUND: The p16 gene product is a negative regulator of cell cycle and has been shown to be deleted or mutated in a number of tumor cell lines and primary tumors. The role of p16 in prostate cancer is not defined. Prostate cancer tissues and cell lines were evaluated for p16 gene alterations....
Topics
- Blotting, Northern
- Blotting, Southern
- Carrier Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Probes
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Humans
- Male
- Microsatellite Repeats
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms
- Tumor Cells, Cultured