Article
Mutational alteration of the p16CDKN2a tumor suppressor gene is infrequent in Ewing's sarcoma.
Oncology reports - 1 Jan 2000
Park Y K, Chi S G, Kim Y W, Park H R, Unni K K
Abstract excerpt
Mutational alteration of the p16CDKN2a tumor suppressor gene has been frequently observed in a variety of human cell lines and tumor tissues. To assess whether alterations of the p16CDKN2a gene play an important role in the pathogenesis of Ewing's sarcoma, we examined the allelic deletion and point mutation of the gene in 27 primary tumors. In quantitative DNA/PCR analysis for three individual exons of the gene,...
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