Article
Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells.
Cancer research - 1 Jul 1995
Brenner A J, Aldaz C M
Abstract excerpt
To define the extent of involvement of chromosome 9p in breast carcinogenesis, we performed microsatellite length polymorphism analysis of markers spanning this region. Of 24 primary breast carcinomas analyzed, we observed a high frequency (58%) of loss of heterozygosity or allelic imbalance affe...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Carcinoma
- Carrier Proteins
- Cell Line
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Primers
- Gene Deletion
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Polymorphism, Single-Stranded Conformational
- Tumor Cells, Cultured