Article
No CDKN2 mutations in neuroblastomas.
Cancer research - 15 May 1995
Beltinger C P, White P S, Sulman E P, Maris J M, Brodeur G M
Abstract excerpt
Mutations of CDKN2 have been found recently in melanoma and many other tumor types. Neuroblastoma shares with melanoma a neuroectodermal origin and a high incidence of deletions of the short arm of chromosome 1. Therefore, we analyzed 18 primary neuroblastomas and 9 tumor-derived cell lines for mutations in CDKN2. We used PCR-single-strand conformation polymorphism to examine exons 1 and 2 of the CDKN2 gene for...
Topics
- Chromosomes, Human, Pair 9
- DNA Mutational Analysis
- Humans
- Mutation
- Neuroblastoma
- Oncogenes
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sensitivity and Specificity
- Tumor Cells, Cultured