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Article

p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 1996

Hirama T, Miller C W, Wilczynski S P, Koeffler H P

Abstract excerpt

The p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is frequently altered in cell lines and some types of cancers. To assess whether alterations of this gene are important in the pathogenesis of cervical cancer, we examined 41 primary tumors and 8 cell lines, usin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8821952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8821952-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.PMID 8821952Read ↗

Alteration of p16 and p15 genes in human uterine tumours.Semantic proximity Read ↗

p16INK4 and p15INK4B alterations in primary gynecologic malignancy.Semantic proximity Read ↗

Absence of p16 gene (CDKN2) deletions in microdissected primary breast carcinoma specimens.Semantic proximity Read ↗

Alterations of the P16 gene in uterine cervical carcinoma from Indian patients.Semantic proximity Read ↗

Absence of mutation in the p53 and the retinoblastoma susceptibility genes in primary cervical carcinomas.Semantic proximity Read ↗

p16 mutations/deletions are not frequent events in prostate cancer.Semantic proximity Read ↗

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.Semantic proximity Read ↗

p16 methylation does not affect protein expression in cervical carcinogenesis.Semantic proximity Read ↗

Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.Semantic proximity Read ↗

Mutational alteration of the p16CDKN2a tumor suppressor gene is infrequent in Ewing's sarcoma.Semantic proximity Read ↗

Lack of mutation at p16INK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma.Semantic proximity Read ↗

p16INK4a Modulates p53 in Primary Human Mammary Epithelial CellsSemantic proximity Read ↗

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