Article
Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancer.
British journal of cancer - 1 Oct 1995
Berns E M, Klijn J G, Smid M, van Staveren I L, Gruis N A, Foekens J A
Abstract excerpt
Changes which lead to excessive cyclin production or to loss of cell cycle inhibition by proteins such as p16/MTS1 may release breast tumour cells from the constraints of cell division. In order to establish the frequency of MTS1/p16 gene alteration and its relation with genetic damage to the p53 and cyclin D1 genes, we have studied these gene abnormalities in 164 human primary breast cancers and in six breast...
Topics
- Base Sequence
- Breast Neoplasms
- Carrier Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- Enzyme Inhibitors
- Female
- Humans
- Molecular Sequence Data
- Mutation
- Protein Kinase Inhibitors