Increased class Ib antigen display on TAP-2 mutant cells by a mitochondrial function inhibitor.

Abstract excerpt

Class I histocompatibility antigen display is defective in the RMA-S mutant cell line due to a mutation in the Tap-2 gene, which encodes a peptide transporter. Incubation of RMA-S cells with oligomycin, an inhibitor of mitochondrial ATPase, strongly increased lysis by cytotoxic T lymphocytes (CTL...

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 3
• ATP-Binding Cassette Transporters
• Adenosine Triphosphatases
• Animals
• Antigen Presentation
• Carbonyl Cyanide m-Chlorophenyl Hydrazone
• Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
• Cell Line
• Dicyclohexylcarbodiimide
• Enzyme Inhibitors
• Histocompatibility Antigens Class I
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Mice, Inbred C57BL
• Mitochondria
• Mutation
• Oligomycins