Article
p21WAF1 mutations and human malignancies.
Leukemia & lymphoma - 1 Jun 1997
Shiohara M, Koike K, Komiyama A, Koeffler H P
Abstract excerpt
During the past few years, several categories of cyclin-dependent kinase inhibitors (CDKIs), which negatively regulate cyclin/cyclin-dependent kinase (CDK) activities, were cloned. The p21WAF1, also known as CIP1 or SDI1, was the first reported CDKI: it's expression is induced by wild-type p53. T...
Topics
- Animals
- Cell Cycle
- Cyclin-Dependent Kinases
- Humans
- Mutation
- Neoplasms
- Proto-Oncogene Proteins