Article
Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas.
Oral oncology - 1 May 1998
Yook J I, Kim J
Abstract excerpt
The p53 tumour suppressor gene is frequently mutated in oral squamous cell carcinomas. However, the downstream mechanism of p53 during oral carcinogenesis is not fully understood. The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21), which can be induced by wild-type p53, functions as a downs...
Topics
- Adult
- Aged
- Carcinoma, Squamous Cell
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Inhibitors
- Female
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mouth Neoplasms
