Article
Analysis of p21WAF1/CIP1 in primary bladder tumors.
Oncology research - 1 Jan 1996
Lacombe L, Orlow I, Silver D, Gerald W L, Fair W R, Reuter V E, Cordon-Cardo C
Abstract excerpt
The p21WAF1/CIP1 gene is regulated by p53 and encodes a cyclin-dependent kinase (Cdk)-inhibitor involved in senescence and cell quiescence. The role of p21 as a negative regulator of cell proliferation suggests that it may function as a tumor suppressor gene. However, only a few mutations of the...
Topics
- Aged
- Aged, 80 and over
- Carcinoma, Transitional Cell
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Urinary Bladder Neoplasms