Expression and sequence analysis of the p21(WAF1/CIP1) gene in renal cancers.

doi:10.1016/S0090-4295(96)00493-1

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Article

Expression and sequence analysis of the p21(WAF1/CIP1) gene in renal cancers.

Urology - 1 Mar 1997

Papandreou C N, Bogenrieder T, Loganzo F, Albino A P, Nanus D M

Abstract excerpt

OBJECTIVES: The p21(WAF1/CIP1) cyclin-dependent kinase inhibitor is an Mr 21,000 protein that can arrest cell growth by associating with and inhibiting cyclin-dependent kinase complexes necessary for cells to exit G1. It is a downstream effector in the p53 growth control pathway and can be transcriptionally activated by increasing levels of p53 protein. The objective of this study was to determine if there are...

Topics

Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA, Complementary
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
Mutation
Polymorphism, Single-Stranded Conformational
Sequence Analysis, DNA
Tumor Cells, Cultured

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Identifiers

PMID: 9123723
DOI: 10.1016/S0090-4295(96)00493-1

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