Article
Analysis of wild-type and mutant p21WAF-1 gene activities.
Molecular and cellular biology - 1 Apr 1996
Lin J, Reichner C, Wu X, Levine A J
Abstract excerpt
The p21WAF-1 gene is positively regulated by the wild-type p53 protein. p21WAF-1 has been shown to interact with several cyclin-dependent kinase complexes and block the activity of G1 cyclin-dependent kinases (cdks). Mutational analysis with the p21WAF-1 gene localized a site, at amino acid resid...
Topics
- Amino Acid Sequence
- Cell Division
- Cyclin D
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53