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p21WAF1 and tumourigenesis

16 Nov 2012

Abstract excerpt

PURPOSE OF REVIEW: This review provides an overview of the structure, regulation and physiological functions of p21, the product of the cyclin-dependent kinase inhibitor 1A (CDKN1A) gene, with a focus on its dual role in promoting and repressing biological processes that are hallmarks of tumourigenesis. RECENT FINDINGS: Recent work has provided a better understanding of the molecular mechanisms of how oncogenic...

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PMID: 23159848
DOI: 10.1097/cco.0b013e32835b639e

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