Molecular analysis of the Cip1/Waf1 (p21) gene in diverse types of human tumors.

doi:10.1016/0167-4781(95)00110-3

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Article

Molecular analysis of the Cip1/Waf1 (p21) gene in diverse types of human tumors.

Biochimica et biophysica acta - 19 Sept 1995

Watanabe H, Fukuchi K, Takagi Y, Tomoyasu S, Tsuruoka N, Gomi K

Abstract excerpt

We have screened for mutations in the Cip1/Waf1 gene using Southern blot analysis and the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method in diverse human tumors. Seven of 102 (7%) human tumor samples were identified to have point mutations within the coding re...

Topics

Base Sequence
Blotting, Southern
DNA Probes
Gene Rearrangement
Genes, Tumor Suppressor
Humans
Molecular Sequence Data
Mutation
Neoplasms
Polymerase Chain Reaction

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