Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.

doi:10.1038/bjc.1996.333

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Article

Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.

British journal of cancer - 1 Jul 1996

Slebos R J, Baas I O, Clement M, Polak M, Mulder J W, van den Berg F M, Hamilton S R, Offerhaus G J

Abstract excerpt

Inactivation of the p53 tumour-suppressor gene is common in a wide variety of human neoplasms. In the majority of cases, single point mutations in the protein-encoding sequence of p53 lead to positive immunohistochemistry (IHC) for the p53 protein, and are accompanied by loss of the wild-type all...

Topics

Adenocarcinoma
Aged
Alleles
Biomarkers, Tumor
Chromosomes, Human, Pair 17
Colorectal Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA, Neoplasm
Female
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Immunohistochemistry

Intestinal Mucosa

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Identifiers

PMID: 8688317
DOI: 10.1038/bjc.1996.333
PMCID: PMC2074586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8688317-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.