Article
Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.
British journal of cancer - 1 Jul 1996
Slebos R J, Baas I O, Clement M, Polak M, Mulder J W, van den Berg F M, Hamilton S R, Offerhaus G J
Abstract excerpt
Inactivation of the p53 tumour-suppressor gene is common in a wide variety of human neoplasms. In the majority of cases, single point mutations in the protein-encoding sequence of p53 lead to positive immunohistochemistry (IHC) for the p53 protein, and are accompanied by loss of the wild-type allele. Recently, the WAF1/Cip1 gene was identified as one of the genes induced by wild-type p53, and increased expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.