Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines.

doi:10.1002/(SICI)1098-2744(199608)16:4<221::AID-MC6>3.0.CO;2-I

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Article

Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines.

Molecular carcinogenesis - 1 Aug 1996

Terry L A, Boyd J, Alcorta D, Lyon T, Solomon G, Hannon G, Berchuck A, Beach D, Barrett J C

Abstract excerpt

p21/WAF1/CIP1/SDI1 is an important cell-cycle mediator with tumor suppressor gene capabilities, and its inactivation could potentially lead to tumor progression. Because tumor suppressor genes are commonly inactivated by somatic and germline mutations, we analyzed a variety of human tumor cell li...

Topics

Base Sequence
Cell Division
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA Mutational Analysis
DNA, Neoplasm
Humans
Molecular Sequence Data
Mutation
Neoplasms
Polymorphism, Genetic
Tumor Cells, Cultured

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